However, when the immune system is stimulated, its levels can rapidly rise to as high as 10,000 mg/L within 12 days [6]
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Hence, one potential explanation for the increased efficacy of tirzepatide on glycemic control relative to the monoagonist GLP-1RA is that targeting both incretin receptors maintains some insulinotropic activity even in subjects who are relatively insensitive to GLP-1
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